alexa Abstract | Novel spectrophotometric estimation of frusemide using hydrotropic solubilization phenomenon

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


A novel, safe and sensitive method of spectrophotometric estimation in ultraviolet region has been developed using 0.5 M ibuprofen sodium solution as hydrotropic solubilizing agent for the quantitative determination of frusemide, a poorly water-soluble diuretic drug in tablet dosage form. Frusemide shows maximum absorbance at 330 nm. Beer's law was obeyed in the concentration range of 20 to100 mg/ml. Ibuprofen sodium does not absorb above 300 nm. Commonly used tablet excipients and ibuprofen sodium did not interfere in spectrophotometric estimation. Results of the analysis were validated statistically and by recovery studies. Using 0.5 M ibuprofen sodium solution for analysis of two different tablet formulations of frusemide, the percent label claims and percent recoveries estimated were close to 100 with low values of standard deviation, percent coefficient of variation and standard error.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): RK Maheshwari S Deswal D Tiwari N Ali B Pothen S Jain

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version