alexa Abstract | Novel synthetic methodology for the synthesis of dibenzo azepines

Journal of Chemical and Pharmaceutical Research
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New synthetic methodology for the synthesis of dibenzo[b,e][1,4]diazepines, a key intermediates in the manufacturing of Clozapine which is indicated for use in therapy as dopamine receptor antagonist, Antipsychotic drug [1]. Synthesis of 2-(4-chloro-2-nitrophenylamino) benzoic acid methyl ester by simple rearrangement of2-[[2- (4-chloro-2-nitrophenoxy)acetyl]amino]benzoic acid methyl ester. The present work describes a novel, cost-effective and easily scalable process of dibenzo[b,e][1,4]diazepines.

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Author(s): Nitin A Shimpi and Rajesh B Dhake


Clozapine, Dopamine receptor antagonist, dibenzo[b,e][1,4]diazepines, dibenzo azepines

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