alexa Abstract | Optimization of Floating Microspheres of Captopril Using Full Factorial Design

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Captopril is an angiotensin converting enzyme inhibitor, widely used in management of hypertension. It has very short half life of 2 h and oral bioavailability of 70%. The present investigation is concerned with the development of the floating microspheres of Captopril to target the drug to its absorption site by increasing the residence time of drug in stomach and to control drug release in therapeutic range for longer period of time. Floating microspheres of Captopril were prepared by Non-aqueous solvent evaporation technique using 32- Full factorial design. In this dosage form, hydrophobic water impermeable polymer (EC) for controlling the release of drug and hydrophobic water permeable polymer (Eudragit RL-100) were used for initial release of drug. Optimization process was carried out with respect to various dependent variables like T50%(h),T80% (h), log K of Pappas eq., release at 12 h, release at 18 h, K of 1st order etc. and optimized formulations were developed. Among three optimized formulations, results of OF1 and OF2 closely met to targeted data while OF3 was found to be best formulation as per cost-effectiveness which also showed significant results to targeted data. Two months of stability study was carried out at room temperature for all three optimized formulations and results showed no significant changes in percentage drug entrapment efficiency and in-vitro drug release study after stability study. So the all three optimized formulation containing 50 mg of Captopril, released drug for 24 h within desired therapeutic concentration.

To read the full article Peer-reviewed Article PDF image

Author(s): Sanket Gandhi Anil Bhandari Girish K Jani Nishant Upadhyay Rucha Pathak


Captopril, Floating drug delivery system, Floating microspheres, Optimization process, Stability study

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version