alexa Abstract | Optimization of in-situ gelling system for nasal administration of celecoxib

Journal of Chemical and Pharmaceutical Research
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Abstract

Nasal drug delivery has become more prominent compared to other conventional routes as it improves both systemic and local availability and effects of drugs. The in-situ gels are colloidal sol which undergoes sol to gel transition through internal trigger like temperature or pH, when administered in-vivo at the target sites like ocular, nasal, vaginal, etc. Administration of Celexocib as in-situ gelling system for nasal route could enhance the bioavailability and therapeutic activity of the drug. In this paper, optimization of the in-situ gelling system of Celecoxib using polymers like pluronic F127, carbopol 934P and the effect of incorporating inclusion complex of drug with β-cyclodextrin into the insitu gels were studied. The rheology of the sol and gel systems was found show pseudoplastic behaviour, and with incorporation of drug inclusion complex, the gel viscosity was found to decline. The dissolution studies showed 100% drug release for the gels containing inclusion complex of drug, as compared to in-situ gels with plain drug providing sustained release maximum 12% drug at the end of 6 hours. Characterization studies such as FTIR, XRD, DSC and SEM confirmed the formation of inclusion complex of drug, and also no significant interaction between drug and polymers when incorporated into the in-situ gelling system. Celecoxib thermoresponsive nasal in-situ gelling system with 15% pluronic F127 was optimized to provide sustained release effect. The addition of cyclodextrin complexed drug in the formulation prove enhancement in the dissolution of the hydrophobic drug in aqueous environment, whereby in-vivo bioavailability can be improved

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Author(s): Abhirami M Brindha R Gomathi S Vedha Hari B N and Ramya Devi D

Keywords

In-situ gels, Celecoxib, pluronic F127, carbopol 934P, β-cyclodextrin., celecoxib

 
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