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Extended-Spectrum β-Lactamases (ESBL)-producing Escherichia coli isolates have emerged as a global threat to public human health, and have been isolated from human, animal and environment origins. Worldwide as well as in Tunisia, high prevalence of ESBL-producing Enterobacteriaceae, especially E. coli, of humans, animals and food-producing animal origin have been increasingly reported. Recent studies have suggested that these E. coli strains, and their antibiotic resistance genes, can spread from food-producing animals, via the food-chainfood chain, to humans. Our review will focus on the evolution and the emergence of ESBLproducing E. coli, coli of animal origin in Tunisia as well as the types of the blaESBL genes in relation with the predominant ESBL-genes circulating Tunisian’s hospitals. Therefore, we have analysed the reported results from Tunisia during the last 10 years. This review showed the predominance of CTX-M group especially in chicken samples, heterogeneity of reported strains and the spread of particular plasmids belonging to the incompatibility group IncI1 and IncF. We conclude that the spread of CTX-M group in Tunisia reflects the global emergence of CTX-M β-lactamases in E. coli of human or animal origins.
CTX-M, Escherichia coli, Animal origin, Tunisia, Pathogenic Bacteria, Viral Disease