alexa Abstract | Oxidative stress and cytokine role of patients with sickle cell disease

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The present study is undertaken to demonstrate the oxidant-antioxidant status including serum lipid peroxidation product malondialdehyde (MDA), serum total antioxidant capacity (TAC), paraoxonase (PON), tumor necrosis factor-α (TNF-α) and vascular endothelial growth factor (VEGF) in Egyptian children with sickle cell anemia. Thus, the levels of MDA, TAC, PON, and TNF-α and VEGF were measured in 52 children with homozygous sickle cell anemia (30 males and 22 females) and 25 healthy age- and gender matched controls. The present results markedly declared significant elevated serum MDA level, while, serum AC and paraoxonase levels were significantly reduced in children with SCA as compared to control subject. On the other hand, cytokines levels, TNF-–α and VEGF levels were elevated significantly (P≤0.01) in SCA children as compared to normal control group. .There were significant change in the levels of MDA, TAC, PON, and TNF-α and VEGF were detected in sickle cell patients treated with hydroxyurea (HU) as related to untreated one. It was found that MDA level was found to be independent on PON and TAC. Also, an insignificant relationship were detected between serum MDA, TAC, PON and TNF-α and VEGF levels. Thus, it could be concluded that, the steady state between oxidant and antioxidant declaring the chronic oxidative stress, increased VOC frequency, decrease in PON level as well as increase cytokine levels in these patient.

To read the full article Peer-reviewed Article PDF image

Author(s): Eman R Youness Amina AbdelSalamHanan F AlyWalaa A AbulHamd Marwa M ElSonbaty and Sherien M ElDaly

Keywords

Total antioxidant, Tumor necrosis factor-α, paraoxonase, vasoendothelia growth factor, Oxidative stress

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords