alexa Abstract | Pattern of Antimalarial Drug Use in Malaysia

Indian Journal of Pharmaceutical Sciences
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Abstract

This work aims to identify the pattern of antimalarial use in Malaysia as a baseline data on common drugs used in the local setting. Data on malaria prevalence and drug use pattern over the past 10-years was collected retrospectively from Vector Borne Disease Sector and Pharmaceutical Services Division, Ministry of Health. The defined daily dose/inhabitant/years is used to describe the antimalarial utilization pattern. We observed a decline of 42% malaria cases within a span of 10 years despite a steady increase in the number of P. knowlesi cases noted in Malaysia. Infections caused by the P. falciparum and P. vivax species demonstrated a reduction in cases within the span of 10 years. Between 2005 and 2013 both chloroquine and primaquine were noted to be the most common antimalarial drugs used, followed by pyrimethamine-combination and quinine. Artemisinin in particularly artesunate and mefloquine use were found to be limited during the study period. Despite being one of the oldest drugs, the quinolines were found to be the most common antimalarials used. The use of primaquine is highlighted due to the gradual increase in the use of the drug in recent years. Indeed, the general decrease in antimalarial use is attributed to the distinct reduction in malaria cases in the country.

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Author(s): N M Ariffin F Islahudin M MakmorBakry E Kumolosasi R N Mudin U K Shamsudin M H A Hamid W M Keong A H S M Haq and S F Abu

Keywords

MThe prevalence of malaria infection in Malaysia has steadily declined, however certain parts of this country are still at risk of malaria infection. Both vector control efforts and accessibility of antimalarial drugs are vital in reducing malaria transmission. At present, one of the challenges in managing malaria is the limited therapeutic options available due to the lack of newer pharmacological agents and recent emergence of antimalarial drug resistance. In view of this monitoring the trends of antimalarial use is vital in ensuring effectiveness of drugs. This work aims to identify the pattern of antimalarial use in Malaysia as a baseline data on common drugs used in the local setting. Data on malaria prevalence and drug use pattern over the past 10-years was collected retrospectively from Vector Borne Disease Sector and Pharmaceutical Services Division, Ministry of Health. The defined daily dose/inhabitant/years is used to describe the antimalarial utilization pattern. We observed a decline of 42% malaria cases within a span of 10 years despite a steady increase in the number of P. knowlesi cases noted in Malaysia. Infections caused by the P. falciparum and P. vivax species demonstrated a reduction in cases within the span of 10 years. Between 2005 and 2013 both chloroquine and primaquine were noted to be the most common antimalarial drugs used, followed by pyrimethamine-combination and quinine. Artemisinin in particularly artesunate and mefloquine use were found to be limited during the study period. Despite being one of the oldest drugs, the quinolines were found to be the most common antimalarials used. The use of primaquine is highlighted due to the gradual increase in the use of the drug in recent years. Indeed, the general decrease in antimalarial use is attributed to the distinct reduction in malaria cases in the country.alaria, drug use pattern, antimalarial drugs, defined daily dose

 
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