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Original Articles Open Access
Present communication deals with the study of Pharmacognostical, phytochemical screening and antihepatotoxic activity prediction of compounds isolated from Callicarpa macrophylla Linn in order to search lead compound. Dried leaves and bark powder material was used for determination of ash value, extractive value, and phytochemical constituents. fifteen compounds from the whole plant of Callicarpa macrophylla were subjected to molecular properties prediction and drug-likeness by Lipinski rule of five & Molinspiration software. Phytochemical screening proved the presence of chemical constituent like tannins, alkaloids, proteins, starch, flavanoids, and glycoside. 12 compounds of the plant fulfill the requirements of Drug likeness were taken for biological activity calculation with the help of Molinspiration software and compared with standard drug Silibinin. On comparison of compounds with silibinin, Calliterpenone, Luteolin, Apigenin, Ursolic acid, Crategolic acid, β- Sitosterol, Betulinic acid, α-Amyrenol, Daucosterol, Luteolin-7-O-glucuronide, Apigenin-7-O-glucuronide and Calliterpenone monoacetate almost fulfills the Lipinski rule of five and showed good bioactivity score than Silibinin. Out of 15 compounds Calliterpenone, Ursolic acid, Crategolic acid, β-Sitosterol, Betulinic acid, Luteolin-7-Oglucuronide, Apigenin-7-O-glucuronide and Calliterpenone monoacetate has good bioactivity score as compared to Silibinin which is potent hepatoprotective drug. So these compounds can be considered as lead compounds with hepatoprotective activity from Callicarpa macrophylla.
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Author(s): Ramesh Patela Parjanya Kumar Shuklaab Amita Vermab and Mahendra Pratap Singhb
Callicarpa macrophylla, Hepatoprotective, Insilico lead finding, Molinspiration, Lipinski’s rule, Phytochemical screening, phytochemical constituents.