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Some imidazolines were synthesized from oxazolinones and upon treatment with benzaldehyde the Schiff's bases were synthesized from the respective imidazolinones. All these compounds were evaluated for analgesic, hypnotic and CNS depressant property and the LD50 of 4 campounds as representative of each series were determined. Some of the synthesized compounds were found to exhibit significant pharrnacodynamic properties.
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Author(s): J K Gupta B De V S Saravanan