alexa Abstract | Pharmacoscintigraphy : An Unexplored Modality In India

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

Establishment of a new molecule as a therapeutic agent requires extensive inputs in terms of money, energy and time. Therefore the worldwide pharmaceutical R and D are focusing its attention on the development of new drug delivery systems. After designing a new delivery system, its optimization Involves the in vitro and in vivo studies. Pharmacopoeial dissolution testing is an important in vitro test to study the release of the drug from its formulation. In vivo studies can be carried out either by blood sampling method or urine analysis. Besides, being cumbersome and tedious these methods do not give any information regarding the biopharmaceutics. Pharmacoscintigraphy, a much-touted technology can answer all above-mentioned queries regarding a delivery system. g-Emitting radionuclide (preferably 99mTc) is tagged with the active constituent or the excipient of the formulation. The radioactive dosage form is administered via Intended route of administration and the subject (humans/animals) is scanned under a gamma camera. Radionuclides tagged with drugs/formulations/devices can provide vital information regarding the extent, rate, site, and mode of drug release and morphology of the drug delivery system during release in humans under the ethical norms. Pharmacodynamics and pharmacokinetics of new drug molecules studied by this technique gives qualitative as well as quantitative data. Present study proposes an effective approach for the development and evaluation of new drug molecules and drug formulations.

To read the full article Peer-reviewed Article PDF image

Author(s): A K Singh Nidhi Bhardwaj A Bhatnagar

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords