alexa Abstract | Phylogenetic Tree and Antiviral Resistance Analysis of Neuraminidase Gene of Influenza A Virus in H1N1 Strains Found in 2010 and 2013

Translational Biomedicine
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Research Article Open Access

Abstract

This study brings the analysis of phylogenetic tree and amino acid sequences of Neuraminidase (NA) from the influenza A virus that can infect a wide variety of birds and mammals. We have analyzed strains of two different years (2010 and 2013) of H1N1 from different country to see the antiviral resistance patterns with respect to reported mutant positions of amino acids. We found the similar types of amino acids near the reported mutated positions that may reduce sensitivity to Neuraminidase. The analysis of phylogenetic tree revealed some diverse strains of influenza A virus indicated the antigenic drift and antigenic shift.

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Author(s): Repon Kumer Saha Hannan Mir

Keywords

Phylogenetic tree, Sequence similarities, Antiviral resistance, DNA mutation, Molecular Virology,Translational Research and Clinical Intervention,H1N1 Flu

 
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