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Original Articles Open Access
Mixed ligand complex of Zn(II) with ranitidine as one ligand and glycine as second ligand was prepared. The complex was characterized on the basis of elemental analysis, electronic and IR spectral and particle size measurements. Pharmacological effects of the complex on gastric secretion in pylorous ligated rats and gastric emptying rate in albino rats were also studied. It was found that the complex in dose range of 200-500 mg/kg produced significant reduction in total and free acid and it had no effect on gastric emptying rate.
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Author(s): Prachi Aryab Savita Shrivastavab Neha Singhc and Sulekh Chandraa
Zn, Ranitidine, Glycine, Particle size, Gastric secretion.