alexa Abstract | Physicochemical characterization of vancomycin and its complexes with ?-cyclodextrin

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The equimolar complexes of vancomycin, a broad-spectrum glycopeptides antibiotic with β- cyclodextrin were prepared to evaluate their suitability for the development of a prolongedrelease form of the antibiotic. Complex preparations were subjected to kneading and freezedrying techniques and characterized using X-ray powder diffractometry (XRD), Thermogravimetric analysis (TGA), Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The uniformity obtained from all of the analyzed results, suggests the successive formation of the aforementioned binary systems. The in vitro dissolution profiles of vancomycin were determined accordingly in a simulated cerebrospinal fluid where the results showed a modified release with improved bioavailabity of vancomycin was achieved upon complexation with beta-cyclodextrin. Our results therefore demonstrated that the use of cyclodextrin could be advantageous not only for lipophilic drugs but also for hydrophilic drugs.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): MS Zarif AR Afidah JM Abdullah AR Shariza


cyclodextrin, vancomycin, complex

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version