alexa Abstract | Physico-chemical characterization, UV spectrophotometric method development and validation studies of Esomeprazole Magnesium Trihydrate

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Esomeprazole magnesium trihydrate (EMT) is a proton pump inhibitor used against peptic ulcer disease to suppress excess acid secretion in the stomach. Physico chemical characterization studies showed that EMT has showed a melting point of 177.330 C. The solubility of drug esomeprazole followed the order methanol>ethanol> acetone> buufer pH 9.0 > distilled water. The analytical method developed for the estimation of esomeprazole magnesium trihydrate in bulk fluids showed maximum absorbance λmax of 203.5 nm in methanol between 200 nm and 400 nm. Linearity studies indicated that estimation of esomeprazole magnesium trihydrate between 2.00 μg /ml to 10.00 μg /ml was found to be linear with regression equation of y = 0.1546*X - 0.00414; ( r2 = 0.999). The method developed was validated for inter and intra day variation, limit of quantitation studies. The SD values of Inter day and Intra day variation studies indicated that the variation is minimum. Limit of Quantitation of esomeprazole was found to be of 1.00 μg /ml. The above analytical parameters indicated that the developed UV Spectrophotometric method of esomeprazole was simple, accurate and reproducible.

To read the full article Peer-reviewed Article PDF image

Author(s): Putta Rajesh Kumar Somashekar Shyale Mallikarjuna Gouda M and S M Shanta Kumar


Esomeprazole magnesium trihydrate (EMT), UV Spectrophotometric Method.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us