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The research work covers the phytochemical screening and Analgesic studies of the root bark of Hymenocardia acida, Tul, (Euphorbiaceae) which is claimed by the Hausa in the Northern Nigeria to be used traditionally for the treatment of headache, chest-pain, rheumatic pain, toothache, ear pain, migraine and sickle cell crisis. The various phytochemical tests revealed the presence of carbohydrates, tannins, alkaloids, flavonoids, saponins and cardiac glycosides. The result of analgesic activity of the extracts showed a significant and dose dependent analgesic activity when compared to the untreated control group at P<0.05. This justifies the use of the plant in ethnomedicine for the treatment of headache, chest pain, rheumatic pain, toothache, ear pain, migraine and sickle cell crisis.