alexa Abstract | Pituitary Adenylate Cyclase Activating Polypeptide Enhances Glucose-Evoked Insulin Secretion in the Canine Pancreas In Vivo

JOP. Journal of the Pancreas
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

Objective To study a local effect of pituitary adenylate cyclase activating polypeptide (PACAP1-27) on glucose-evoked insulin release under in vivo conditions.
Intervention Glucose and PACAP1-27 were locally infused to the pancreas via the superior pancreaticoduodenal artery without interrupting the blood supply.
Main outcome measures Plasma insulin and glucose concentrations were determined in samples obtained from the superior pancreaticoduodenal vein and the aorta. Superior pancreaticoduodenal venous blood flow was measured to compute the net output of insulin.
Results PACAP1-27 (0.005-5 µg) increased the basal insulin secretion by about 15 folds in a dose-dependent manner. Local infusion of either glucose (5%) or PACAP1-27 (0.05 µg) resulted in a significant increase in the basal insulin output to about 300 µU·min-1g-1, which was highly reproducible upon the second administration of the same dose with an interval of 30 min. When PACAP1-27 was simultaneously given during glucose infusion, the increased insulin output due to glucose was further enhanced to about 600 µU·min-1g-1. The net increase in PACAP1-27-induced insulin output in the presence of glucose was significantly greater than that obtained with PACAP1-27 alone. There exists a strong and highly significant correlation between changes in glucose level and those in insulin output when both glucose and PACAP1-27 were administered simultaneously.
Conclusion The results indicate that PACAP1-27 directly enhances the glucose-evoked insulin secretion in the endocrine pancreas in anesthetized dogs. The study suggests that PACAP may play a local facilitating role in insulin secretion in response to glucose loading.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Nobuharu Yamaguchi

Keywords

Adenylate Cyclase, Chemical Actions and Uses, Dogs, Hormones, Hormones, Hormone Substitutes, and Hormone Antagonists, Regression Analysis

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords