alexa Abstract | Polymeric recrystallized spherical agglomerates of felodipine by quasi-emulsion solvent diffusion method

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


The objective of the present work was to study the effect of different polymers on the solubility and dissolution rate of Felodipine (FL) a poorly water soluble antihypertensive, by spherically agglomeration using acetone, water and dichloromethane as good solvent, poor solvent and bridging liquid, respectively. The quasi-emulsion solvent diffusion technique was used as a method for spherical agglomeration. The hydrophilic polymers like polyvinyl pyrrolidone, polyvinyl alcohol, and polyethylene glycol were used in agglomeration process. The pure drug (FL) and its agglomerates with different polymers were characterize by differential scanning calorimetry (DSC), Powder X-ray diffraction (PXRD), IR spectroscopic studies and scanning electron microscopy (SEM). The DSC results indicated that decrease in melting enthalpy related to disorder in the crystalline content. PXRD studies also showed changes in crystallanity, IR spectroscopy revealed that there were no chemical changes in the recrystallized agglomerates. The spherical agglomerates with different polymers exhibited marked increase in solubility (41.01 μg mL-1) and dissolution rate (98.83% in 120 mins) as compared with FL. The SEM studies showed that the agglomerates posseeses a good spherical shape. The recrystallized agglomerates also exhibited higher micromeritic properties (bulk density, tapped density and angle of repose).

To read the full article Peer-reviewed Article PDF image

Author(s): Amit R Tapas Pravin S Kawtikwar and Dinesh M Sakarkar


Felodipine, Spherical Agglomerates, Solubility, Dissolution, Micromeritic Properties

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version