alexa Abstract | Possible use of psyllium husk as a release retardant

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

Various hydrophilic polymers from synthetic origin such as methylcellulose, PEGs, HPMC as well as those from natural world such as guar gum, tragacanth, xanthan gum have been used to formulate oral sustained release formulations. Psyllium husk has the ability to swell 10-14 times of its original volume and form a hydrogel. It is biocompatible, inexpensive, inert, non-absorbable, environment friendly and easily available. However, its use as a release retardant has not been fully explored. Owing to large dose, high sensitivity to light, moisture and heat and also very short half-life of 1-2 h; formulation of sustained release dosage form of amoxicillin trihydrate is a challenge. Hence the present study has been undertaken to develop sustained release granules as well as matrix tablets of amoxicillin trihydrate using psyllium husk as a primary release retardant. The drug release of these formulations was compared with those containing HPMC K4M.The results showed insignificant difference in t80% value for drug release as assessed by student's t-test at 5% level of significance. Selected formulations were kept at controlled conditions of 40o/75% RH and 30o/65% RH for a period of 3 mo. Microbiological assay was used as a stability indicating method of assay. Sustained release granules and tablet formulations containing HPMC alone were found to be more stable than the similar formulations containing husk with percent drug content at the end of 3 mo at 40o/ 75% RH being 92.66%, 93.81%, 86.74%, 88.31% and the rate of degradation being 8.46×10-4 d-1, 7.1×10-4 d-1, 1.58×10-3 d-1 and 1.38×10-3 d-1, respectively. Thus it was concluded that psyllium husk can be effectively used as a hydrogel polymer in sustained release formulations. However, there is a need to keep moisture level under control during and after formulation.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Angira Desai Supriya Shidhaye VJ Kadam

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords