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Original Articles Open Access
Postoperative sepsis is the leading cause of morbidity and mortality after major surgery, resulting in hefty financial costs in hospitals all over the world. 40 Fischer rats were injected intra-peritoneally with 0.05 ml Covexin 10 which contains toxoids from different Clostridial species, 2 weeks prior to caecal ligation and puncture. Another 40 Fischer rats, as a control, underwent caecal ligation and puncture without vaccination. 16 of 40 vaccinated rats died (40%), peritoneal fluid cultures from the dead rats grew E. coli only, and 36 of 40 control rats died (90%), peritoneal fluid cultures from the dead rats were: 19 grew E. coli and C. perfringens; 12 grew E. coli,C. perfringens, and enterococci; 3 grew E. coli only; 1 grew E. coli, and enterocci; and 1 grew no organisms. Prophylactic vaccination with clostridial toxoids proved effectiveness in preventing anaerobic infection, and reduce mortality in rats that underwent caecal ligation and puncture; the gold standard model for polymicrobial sepsis. Currently, a pilot study is underway in which human patients who will undergo major surgery are prophylactically vaccinated with clostridial toxoids, in an attempt to eradicate postoperative anaerobic sepsis.
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Author(s): Medhat Khafagy Ahmed M Mayla Ayatallah Khafagy Nabil BarayaGamal Emira Mohamed Eldweik Wael Abdelgawad Moataz GadallaManar M Moneer Mostafa Elberry and Ahmed Orabi
Postoperative, Anaerobic sepsis, Vaccine, Clostridia toxoids, Covexin., Postoperative