alexa Abstract | Potential Investigation of Peceol for formulation of Ezetimibe self nano emulsifying Drug Delivery Systems

Asian Journal of Biomedical and Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The present work was aimed at formulating and physicochemical characterization SNEDDS (self Nano emulsifying drug delivery system) of ezetimibe and evaluating its in vitro and in vivo potential. The solubility of both drugs was determined in excipient screening studies. Pseudoternary phase diagrams were used to evaluate the Nano emulsification existence area, composed of different surfactants, co surfactants, and oils at different surfactant to-cosurfactant (S/CoS) ratios, and the system exhibiting the largest percentage area of the self-Nano emulsifying region was selected and optimum oil ratio in the SNEDDS was selected by evaluating the clarity, precipitation and mean droplet size of the resultant Nanoemulsions. The release rate of ezetimibe was investigated using an in vitro dissolution test. In vitro dissolution studies showed that the SNEDDS composed of Peceol (20% wt/wt), Tween 80 (30% wt/wt), Ethanol (30% wt/wt), and ezetimibe (20% wt/wt) had higher initial dissolution rates for both drugs when compared with plain EZT. More importantly, EZT SNEDDS had a significantly increased dissolution profile in distilled water and pH 4.0 acetate buffer, implying enhanced bioavailability. The underlying mechanism of the loading capacity of EZT was elucidated by measurement of the zeta potential analysis. The results implied that EZT was located both in the Nanoemulsion core and the surfactant–cosurfactant layer. Comparative pharmacokinetic evaluation of EZT SNEDDS was investigated in terms of C max, tmax and AUC using rats. The SNEDDS formulation significantly increases pharmacokinetics parameter as compared with plain ezetimibe. The optimized formulation was then subjected to stability studies and was found to be stable over 6 months. Thus, the study confirmed that the SNEDDS formulation can be used as a possible alternative to traditional oral formulations of ezetimibe to improve its bioavailability

To read the full article Peer-reviewed Article PDF image

Author(s): Prashant PP Vaishali K Santosh P

Keywords

Ezetimibe, Self nano emulsifying drug delivery systems (SNEDDS), Pseudoternary phase diagrams, Pharmacokinetic

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords