alexa Abstract | Preformulation Characterisation, Designing and Formulation of Aceclofenac Loaded Microparticles

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The purpose of the present study was to systematically investigate some of the important physicochemical properties of Aceclofenac loaded micro particles.Aceclofenac is a potent analgesic, anti-pyretic and anti-inflammatory agent used in the management of moderate-to-severe pain and in rheumatoid disorder, rheumatoid arthritis and ankylosing spondylities. Almost all drugs are marketed as tablets, capsules or both. Prior to the development of these major dosage forms, it is essential that pertain fundamental physical and chemical properties of the drug molecule and other divided properties of the drug powder are determined. This information decides many of the subsequent events and approaches in formation development.A per oral extended release micro particles of aceclofenac was prepared by emulsion solvent evaporation method using polymer ethyl cellulose as well as eudragit RSPO and dispersion carrier as Aerosil. So before selection of excipients, the Preformulation study of drug aceclofenac is completed for successful formulation of per oral extended release micro particles. Preformulation studies included solubility, pKa, dissolution, melting point, assay development,, stability in solid state; bulk density, flow properties, excipient compatibility, entrapment efficiency, release profile of micro particles and Marketed brands of modified release product were investigated.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): B Jayanthi S Madhusudhan G P Mohanta PK Manna


Aceclofenac, Ethyl Cellulose, Eudragit RSPO, Aerosil, Micro particles.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version