alexa Abstract | Preformulation studies of a prodrug of ciprofloxacin.

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


A prodrug of Ciprofloxacin was synthesized by reacting the free base with aqueous formaldehyde solution in a 1:1 mixture of methylene chloride and methanol. The colourless, crystalline Nhydroxymethyl derivative, m.p. 238-242 degree C showed enhanced solubility and a three fold increase in the dissolution rate over parent drug. The degradation kinetics, pH-rate profile and antimicrobial activity of the prodrug were also determined.

Author(s): AG Swaminathan SP Agarwal

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