alexa Abstract | Preliminary phytochemical analysis, antihyperglycemic, antinociceptive activity and toxicity studies on leaves of Casearia elliptica Wild

Journal of Chemical and Pharmaceutical Research
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Abstract

In oral glucose tolerance tests with methanolic extract of Casearia elliptica leaves (MECE), the extract dosedependently reduced blood glucose concentrations in glucose-loaded mice. At extract doses of 50, 100, 200 and 400 mg/kg, the reductions in blood glucose levels were, respectively, 6.9, 21.9, 35.8, and 50.0%. In comparison, a standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10 mg per kg, reduced blood glucose level by 47.4%. In analgesic activity tests with acetic acid induced pain model mice, the extract at the aforementioned four doses, dose-dependently reduced acetic acid induced abdominal constrictions in mice by 18.5, 40.7, 48.1, and 51.9% versus the 48.1 and 63.0% reductions obtained with a standard analgesic drug, aspirin, administered respectively, at doses of 200 and 400 mg per kg. The extract when administered to mice did not cause any acute toxicity when administered at doses up to 3000 mg per kg. Preliminar phytochemical analysis showed the presence of alkaloids, flavonoids and tannins in the extract, which can account for the observed antihyperglycemic and antinociceptive activities

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Author(s): Md Shamiul Hasan Khan Md Forhad Molla Samira Sultana Shahnaz Rahman and Mohammed Rahmatullah

Keywords

Casearia elliptica, Flacourtiaceae, OGTT, analgesic, antihyperglycemic

 
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