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Research Paper Open Access
Ibuprofen was esterified with paracetamol and salicylamide to give two mutual prodrugs. The purity of the compounds was confirmed by TLC. Prodrugs were characterized on the basis of elemental analysis, IR spectroscopy, [1H] NMR spectroscopy and mass spectroscopy. The physicochemical properties such as solubility in water and organic solvents like methanol, ethanol, acetone, chloroform and ether, and partition coefficient in octanol-water, octanol-hydrochloric acid buffer (pH 1.2), and in octanol-phosphate buffer (pH 7.4) were determined. The results indicate that the prodrugs are more lipophilic than parent drug i.e. ibuprofen and their dissolution rate was pH-dependent.
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Author(s): A V Bhosale G P Agrawal P Mishra