alexa Abstract | Preparation and Determination of Drug-Polymer Interaction and In-vitro Release of Didanosine Microspheres made of Cellulose Acetate Phthalate or Ethyl cellulose Polymers

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


The objective of this study was to formulate and evaluate the drug-polymer interaction of Didanosine using two polymers with different characteristics as Ethyl cellulose or Cellulose acetate phthalate. Microspheres were prepared by the emulsion solvent evaporation. The effect of drug-polymer interaction was studied for each of microspheres. Important parameters in the evaluation of a microencapsulation technique are encapsulation efficiency, yield production, particle size, surface characteristics of microspheres, scanning electronic microscopy (SEM), powder X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC). The in-vitro release studies are performed in buffer (pH 7.4). Microspheres containing cellulose acetate phthalate and Ethyl cellulose showed 80-87% and 75-79% of entrapment efficiency, respectively. The thermogram X-ray and DSC showed stable character of Didanosine in the microspheres and revealed an absence of drug polymer interaction. The prepared microspheres were spherical in shape and had a size range of 355 μm for Cellulose acetate phthalate microspheres and 345- 383 μm for Ethyl cellulose microspheres. The results suggest that Didanosine was successfully and efficiently encapsulated; the release rates of matrix microspheres are related to the type of polymer, only when formulation (FDEC3) used to get prolonged drug release with increasing the polymers content in the microspheres. Data obtained from in-vitro release for microspheres were fitted to various kinetic models and the high correlation was obtained in the First order model.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Sethi RK Barik B B Sahoo S K


Didanosine, dispersing agent, modified emulsionsolvent evaporation.

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version