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Short Communication Open Access
Enteric coated pancreatin tablets were prepared with five different enteric polymers. These coated tablets were blister packaged using polyvinyl chloride/aluminium foil (PVC/AI-foil) and polyvinylidene chloride/aluminium foil (PVdC/Al-foil). The tablets were evaluated on the basis of their disintegration time, loss on drying and enzyme activities periodically during a period of 90 d. All tablets but one stored at 45Âº and 75% RH (relative humidity) failed to meet disintegration test IP. Tablets coated with cellulose acetate phthalate (CAP) and wincoat polymers failed disintegration test IP even at room temperature. All tablet formulations stored at 45Âº and 75% RH failed loss on drying test IP. It was observed that the activities of pancreatic enzymes decreased on storage, but the loss in activity of individual enzymes were found to be different. Acrycoat L100 with PVdC packaging had shown promising results.
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Author(s): S C Basak P Sampath Kumar R Manavalan K A Narendranath