alexa Abstract | Preparation and Evaluation of Solid Dispersions of Modified Gum Karaya and Aceclofenac: Controlled Release Application

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The objective of the present investigation was to develop matrix solid dispersion (SD) of aceclofenac sodium with modified gum karaya (MGK) in the drug carrier ratio of 1:1, 1:2, 1:4, 1:8 and 1: 10 (SD1 to SD10) and to study its functionality as a matrix forming agent for oral controlled release formulations. MGK was characterized and compared with GK through swelling index, water retention capacity and ATRFTIR. MGK showed comparable swelling index and water retention capacity to GK. The prepared solid dispersions were characterized for their ATRFTIR, drug content, and in vitro release studies followed by various release kinetics and mechanism of release. The drug release profile showed concentration dependent release retardant potential of natural polymer from 99.91 to 72.29 % (SD1 to SD10). Kinetic profile showed good linearity with zero order i.e. exhibiting concentration independent release of drug and Hixson Crowell cube root law (r2 = 0.848 to 0.925) demonstrating that the drug release from the SD was erosion based. Korsmeyer pepas model provide n values of 0.566 to 0.788 suggestive of release mechanism was non-Fickian or anomalous release (0.45 < n < 0.89), which point towards drug release follows both diffusion and erosion mechanism. The drug content was found to be between 99.39 % and 100.83% representative of drug uniformity in various formulation batches.

To read the full article Peer-reviewed Article PDF image

Author(s): Gurpreet Arora Karan Malik Jyoti Sharma Manju Nagpal and Inderbir Singh

Keywords

modified gum karaya, matrix solid dispersion, release mechanism

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords