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The aim of this work is to investigate the efficacy of non-antibiotic microecological complex preparation in the prevention of Escherichia coli - induced diarrhea in swine. A specific non-antibiotic microecological complex was prepared after sterilization and supplementation with probiotics. This preparation was used to prevent Escherichia coli (E.coli) - induced diarrhea in neonatal swine. Self-field epidemic strains were used to prepare vaccine and bacteriophages that were successfully applied to prepare the microecological complex preparation. Results showed no difference of cure rate of diarrhea between swine treated with microecological complex and antibiotic treatment (P>0.05). In the microecological complex treated swine, the recurrence rate of diarrhea was significantly lower than that in the antibiotic treated swine within 1 month (P<0.05). The microecological complex treatment could significantly reduce the incidence of diarrhea in pregnant swine (P<0.05), but treatment had no significant influence on the survival rate of neonatal swine (P>0.05). The microecological complex treatment could significantly reduce the incidence of diarrhea in weaned swine (P<0.05) but had no significant influence on the survival rate of neonatal swine (P>0.05). The specific microecological complex preparation is effective to treat the E. coli - induced diarrhea and can reduce the short-term recurrence of diarrhea in swine. The microecological complex treatment in pregnant swine can reduce the incidence of diarrhea in neonatal swine, and the complex used in neonatal swine can decrease the incidence of diarrhea in weaned swine.
Pathogenic Escherichia coli, diarrhea in neonatal swine, virulent phage, non-antibiotic treatment