alexa Abstract | Prevention of post-surgical adhesions by Achnil in New Zealand white Rabbits

Journal of Chemical and Pharmaceutical Research
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Abstract

Adhesion is an inflammatory repair process that occurs following tissue injury. NSAIDs with their COX inhibition potential are known to prevent adhesions to a certain extent. Their role in thwarting the inflammatory process is responsible for a setback in the repair process ultimately leading to the prevention of adhesions. The present investigation was carried out to prevent post surgical abdominal adhesion by Achnil and diclofenac sodium. 15 female rabbits were randomly assigned to 3 groups containing 5 animals each on the basis of body weight for induction of surgical adhesion and respective treatment. Observations revealed that animals in the control group were weak and emaciated following surgery. Diarrhoea and loss of body weight was evident. Animals in diclofenac sodium group showed minor advantage over control. However, Achnil treatment was able to salvage animals from distress as evidenced by clinical sign data on day-14. No mortality was observed with Achnil treated groups. Oxidative stress and inflammatory parameters like (IL-17 and TNF-α) were improved significantly in the Achnil treated groups as compared to diclofenac sodium. Gross necropsy revealed presence of severe adhesions in the control and diclofenac sodium treated groups. In case of Achnil, adhesions were found to be absent. Adhesion percentage and tenacity were significantly higher in the control groups. diclofenac sodium caused only a modest reduction in the adhesion percentage and tenacity as compared to the Achnil treated groups. Histopathological evaluation showed inflammatory infiltration and collagen deposition in the adhesion tissue on a severe scale in the control group. Inflammatory infiltration was comparable in the Achnil and diclofenac sodium treated groups. Tissue from Achnil treated animals showed only minor infiltration and collagen deposition as compared to control. Based on the results, it was concluded that Achnil is able to prevent surgical adhesions in rabbits.

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Author(s): Manu Chaudhary Prabhakar Singh Gregory Marslin and Vinoth K M Khandelwal

Keywords

aceclofenac, achnil, adhesion, diclofenac, inflammation

 
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