alexa Abstract | Protective effects of graph peel extracts on cardiac hypertrophy in 2-kidney/1-clip hypertensive rats

Journal of Chemical and Pharmaceutical Research
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Aim of this study was investigate to protective effects on cardiac hypertrophy by graph peel extracts (GP) in 2- kidney/1-clip (2K1C) hypertensive rats model. For this purpose we constructed 2K1C rat models and orally administrated GP two times per day for 7 weeks. For determine of anti-hypertensive effects, we measured blood pressure (BP) by tail cuff methods. At the first weeks, observed no changes of BP in all groups, At the 4 and 7 weeks, BP was markedly elevated on 2K1C group to 30 and 50% than sham control group, respectively. Whereas, sham + GP group not observed changes of BP. In 2K1C + GP administrated group, BP was reduced in dose dependent manner but not significant. In contrast, administration of GP was induced reducing of fibronectin expression on cardiac muscle tissue and then suggested cardioprotective effect. These results suggested that graph peel extracts have anti-hypertensive function through reducing of hypertrophy marker on hypertension and its complications.

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Author(s): Chan Moon Jung Sun Eun Choi Sung Jin Hwang and KwangHyun Park


2-kidney/1-clip (2K1C), cardiac hypertrophy, hypertension, blood pressure, fibronectin, graph, cardiac hypertrophy

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