alexa Abstract | Protective properties of traditional herbal formulation triphala against D-Galactosamine induced hepatotoxicity in mice

International Journal of Drug Development and Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

The aim of the present study was to investigate the hepatoprotective effects of Triphala in D-Galactosamine (D-GalN) induced hepatic toxicity in mice. The mice received a single dose of galactosamine (700mg/kg, i.p) to induce hepatotoxicity; Triphala extract (1000mg/kg, i.p) and silymarin (25 mg/kg, i.p.) were administered after the injection of galactosamine. Aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), Tumour necrosis factoralpha (TNF-.), bilirubin, lipid peroxidation (LPO), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidise (GPx), glutathione reductase (GR), glutathione-s-transferase (GST) and total reduced glutathione were estimated in serum of the mice.It was found that D-GalN induced hepatic damage resulted in a significant (p<0.05) increase in the activity of ALT, AST, ALP, bilirubin, LPO and TNF-. level with a decrease in the levels of anti-oxidant enzymes such as SOD, CAT, GPx, GR, GST and Total reduced glutathione which attained normal levels after the treatment of Triphala extract (1000mg/kg/b.wt, i.p). These biochemical observations were supported by histopathological examination of mice liver sections. These observations demonstrate that Triphala treatment may attenuate protective activity against D-galactosamine- induced hepatotoxicity in mice.

| Peer-reviewed Full Article image

Author(s): Evan Prince Sabina Mahaboobkhan Rasool Mahima Vedi Arulmani Geethanjali

Keywords

Hepatotoxicity, Galactosamine, Triphala, Antioxidant

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords