700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ ReadersThis Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
Short Communication Open Access
A series of bis-(acridine-4-carboxamide) analogues possessing significant cytotoxicity against P388 leukemia cell cultures, which were designed as bis-DNA intercalating agents, was subjected to the quantitative structure activity relationship analysis. Quantitative structure activity relationship studies by Fujita-Ban model gave excellent correlations (correlation coefficient, r=0.997) for the 24 compounds included in the final regression analysis. It was observed that substitutions on position 5 favor the activity while any group on position 6 decreases the activity strongly. Theseresults will be useful in designing 'lead' compounds to be useful as bis-DNA intercalators for the therapy of leukemia.
To read the full article Peer-reviewed Article PDF
Author(s): SV Sharma L Venkateshwarlu B Suresh