alexa Abstract | QSAR Study Of Substituted 3,5-Di-Tert-Butyl-4-Hydroxy Styrene : A Series With Antiinflammatory Activity

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Short Communication Open Access


A series of 19 antiinflammatory drugs 3,5-di-tert-butyl-4-hydroxy styrene derivatives were subjected to quantitative structure activity relationship analysis with an attempt to derive a correlation between the biological activity as dependent variable and various descriptors as independent variables by using Hansch approach. The QSAR analysis showed that, the anti-inflammatory activity of the analogues is significantly correlated with thermodynamic and sterimol parameters. The analysis resulted in the following 2-D equation suggest that, BA=(-0.588016) MR1+(0.2815) MR2+(-0.150769) Hdor1(- 1.322597), n=15, r=0.864, r2=0.764, f=7.336, t=2.709, STD=0.64, a lipophillic group, which is less bulkier at R1 and more bulkier at R2, is important in determining the anti-inflammatory activity along the axis of a parent skeleton, which can be used for predicting the affinity of related compound and for guiding the design of a new molecule.

To read the full article Peer-reviewed Article PDF image

Author(s): Geeta Kant Anupama Parate S C Chaturvedi

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version