alexa Abstract | Quality by Design (QbD) Approach for Formulation Development of Hydralazine Hydrochloride Tablets

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The main aim of the present study was to develop a robust and stable immediate release tablet formulation of Hydralazine hydrochloride using quality by design (QbD) approach. Critical material attributes and critical process parameters were identified and linked to the critical quality attributes (CQA’s) of the drug product/formulation. Experimental trials were designed using factorial design technique with considering critical material attributes (CMA’s) and critical process attributes (CPP’s). Physicochemical characterization and drug excipient compatibility studies were performed. Flow characteristics and compressibility of blend material were tested before tablets were compressed by direct compression method. Weight variation, diameter, thickness, hardness, %friability, disintegration time of compressed tablets were evaluated for physical characterization. Design space was identified and risk factors mitigated after the implementation of control strategy

To read the full article Peer-reviewed Article PDF image

Author(s): Rashmi Dahima Amit Gupta and Devashish Rathore

Keywords

Quality by design, Critical quality attributes, Critical material attributes, Design space, IR tablets, Formulation

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us