alexa Abstract | Quantitative Relationships Between Protein Binding Affinities And Physico-Chemical And Structural Parameters Of Some Aniline Derivatives

Indian Journal of Pharmaceutical Sciences
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Paper Open Access

Abstract

The binding of a series of aniline derivatives to bovine serum albumin was investigated using fluorescence spectroscopic technique. Nineteen physico-chemical and structural parameters of drugs could be divided into four groups: steric, electronic, hydrophobic and molecular connectivity parameters. In order to understand the binding mechanism and to predict binding affinity, association constants for drug-protein binding have been correlated to physico-chemical and structural parameters of drugs using statistical methods. Significant correlation could only be obtained on removing from analysis the two relatively low molecular weight drugs, benzocaine and paracetamol. Hydrophobicity of drug was not found to be a significant parameter. The size of the drug molecule and electrostatic interactions play a major role in the binding of these drugs to serum albumin. Quadratic equations gave a better fit of the data. Quantitative relationships between association constant for drug-protein binding and various statistically significant physicochemical and structural parameters of drugs were obtained. The relationships can be useful in the prediction of association constants.

To read the full article Peer-reviewed Article PDF image

Author(s): Neelam Seedher Garima Goel

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords