alexa Abstract | Quantization of dextromethorphan and levocetirizine in combined dosage form using a novel validated RP-HPLC method

Indian Journal of Pharmaceutical Sciences
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Abstract

The present study reveals a simple isocratic RP-HPLC method for the simultaneous determination of dextromethorphan hydrobromide and levocetirizine dihydrochloride in a cough syrup. The separation of these compounds was achieved within 10 min on a Phenomenex (USA) C18 analytical column, 250×4.0 mm i.d., using an isocratic mobile phase consisting of potassium dihydrogen phosphate buffer (pH 2.5) - acetonitrile- tetrahydrofuran (70:25:5, v/v/v). The analysis was performed at a flow rate of 1.2 ml/min and at a detection wavelength of 232 nm. Percentage recovery and RSD were 100.36% and 0.05% for levocetirizine dihydrochloride, 100.35% and 0.27% for dextromethorphan hydrobromide respectively. Quantification of the components in syrup formulation was calculated against the peak areas of freshly prepared standard solutions. The method was validated as per ICH guidelines.

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Author(s): Shalini Joshi C Bhatia CS Bal M S M Rawat

Keywords

Cough syrup formulation, dextromethorphan hydrobromide, levocetirizine dihydrochloride, RP-HPLC, validation

 
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