alexa Abstract | Quest for anthelminitic agents, part II benzothiazole and benzotriazole carbamates and 2-benzazolyl vinyl ketones

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access


Several benzthiazole carbamate analouges 12-17 and 21 of anthelminitic benzimidazole carbamates like mebendazole (1) and fenbendazole(3) are synthesised from the corresponding 2-aminobenzthiazoles. 1,2-Diamino-5,6,7,8-tetrahydronapthalene asffords through the aminonaphthimidazole 23, the carbamate 24 which is a cyclised version of parbendazole (4). 3,4-Diaminobenzophenone upon diazotisation gives the benzotriazole 25 and thence the ester 26. 2-Acetylbenzimidazole (27) and 2-acetylbenzthiazole (28) are condensed with aldehydes to give 2-benzazolyl vinyl ketones 29-34. All the products are found to be inactive in curing hamsters of N. americanus infection.

Author(s): K Nagarajan SB Hendi AN Goud HG Sen BN Deb

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