alexa Abstract | Rapid RP-HPLC Method for Estimation of Nisoldipine from Tablet Dosage Form

Der Pharmacia Sinica
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Research Article Open Access


A new reverse phase HPLC method is developed for the rapid estimation of Nisoldipine, a calcium channel blocker from tablet dosage formulation. Standard solution of concentration 1 mg/mL was prepared in methanol. The analysis was carried out on a Grace Column (4.6 mm I.D x 250 mm) C-18 column using mobile phase Methanol, Acetonitrile and Water. The flow rate was maintained at 1.0 ml/min. Detection was monitored at 237 nm. The retention time of drug was found to be 3.94±0.002 min. The validation of the proposed method was in terms of linearity and range, accuracy and precision. The drug showed the linear response over the concentration range from 20 to 80 μg/mL. The percentage recovery obtained for drug from tablet formulation was 98.75 with relative standard deviation of less than 1%. Since the analysis is completed within 5 minute, the proposed method could be employed for routine analysis Nisoldipine from tablet formulation.

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Author(s): Manohara Yagaina Nagaraj and Mohammed M Safhi

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