alexa Abstract | Recent advancement in imidazole as anti cancer agents: A review

Der Pharmacia Sinica
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Review Article Open Access

Abstract

Cancer is the second leading cause of death world wide after heart disease. A number of noble drugs are discovered for the treatment of cancer. In the present time imidazole plays an important part in the development of new drug for treatment of cancer. Imidazole is a nitrogen containing heterocyclic ring which possesses biological and pharmaceutical importance. Imidazole ring consists of variety of important natural product like histidine and purine. Imidazole derivatives have an important application in cancer treatment and an important agent used in medicinal chemistry. Despite these progresses the majority of patient diagnosed with their major malignancies will die of their disease and therefore, there is a need for few new agents with novel mechanism of action. Though much effect has been focused on the development of novel tyrosine-kinase inhibitors and antibiotics directed at signal transduction, exploration of new compound directly against traditional target of DNA and tubulin continues to be important.

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Author(s): Sanchita Baroniya Zaihra Anwer Pramod K Sharma Rupesh Dudhe Nitin Kumar

Keywords

Imidazole, Benzimidazole, Anticancer, Thiopurines, Pyrimidines

 
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