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Review Article Open Access
In the last two decades enormous research has been carried out to develop self-regulated insulin delivery. Self-regulated delivery system is designed to release the insulin in response to changes in glucose concentration. Various sensing mechanisms like pH dependent polymer erosion, substrate enzyme reaction, competitive binding, drug solubility and various types of devices like hydrogel membranes, matrix system and grafted porous membranes are used to develop self-regulated insulin delivery. These self-regulated insulin delivery systems have the potential to improve the quality of the patient by avoiding repetitive administration of insulin.
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Author(s): H G Shivakumar C S Satish