alexa Abstract | Reconstitution Stability of Ceftriaxone Sodium for Injection in Intravenous Diluents

Der Pharmacia Sinica
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access

Abstract

The objective of this study to evaluate reconstitution stability of Ceftriaxone in different diluents like sterile water for injection, 0.9% Sodium chloride solution, 10% Dextrose, 5% Dextrose + 0.9% NaCl solution, Sodium lactate over 3 days at room temperature and 10 days at refrigerated condition (2-8°C), and 10% invert sugar, 5% Sodium bicarbonate, Freamine III, 10% Mannitol over 24 hrs at room temperature, and Ceftriaxone admixture solution with Metronidazole HCl injection along with the diluents in 0.9% NaCl and 5% Dextrose over 24 hrs at room temperature. No data are available, however, about the Ceftriaxone stability at various temperatures in Freamine III, Metronidazole HCl injection, sodium lactate, 5% Sodium bi carbonate, 10% invert sugar and 10% Mannitol. Ceftriaxone was reconstituted with 19.2 mL of sterile water for injection and then injected to the bags of above mentioned diluents and stored the solutions at room temperature and refrigerator as specified above. The samples of Ceftriaxone solutions in sterile water for injection, 0.9% Sodium chloride solution, 10% Dextrose, 5% Dextrose + 0.9% NaCl solution, Sodium lactate were collected after 3 days at room temperature and 10 days at refrigerated stored, and the solutions in 10% invert sugar, 5% Sodium bicarbonate, Freamine III, 10% Mannitol were collected after 24 hrs at room temperature. The Ceftriaxone solutions in 0.9% NaCl and 5%Dextrose solutions admixed further with Metronidazole HCl injection (7.5 mg/mL). All these samples were tested with a specific stability indicating methods for the estimation of content of Ceftriaxone and Ceftriaxone impurities. A clinically significant loss of potency was defined as a greater than ten percent decrease from its initial concentration. The concentration of Ceftriaxone was 90% or more for 3 days at room temperature, 10 days at 2-8º C and 24 hrs at room temperature. Thus, Ceftriaxone can be stored in the solution having the concentration of 40mg/mL with Sterile water for Injection, 0.9% NaCl solution, 10% Dextrose Solution, 5% Dextrose + 0.9% NaCl solution are stable up to 3 days period at room temperature and 10 days if stored at refrigerated conditions, and concentration of 40mg/mL with Sodium Lactate, 10% Invert Sugar, 5% Sodium bi Carbonate, Freamine III, 10% Mannitol are stable up to 24 hrs at room temperature, and concentration of 10mg/mL with an admixture of Metronidazole HCl (concentration of 7.5mg/mL) + 0.9% NaCl solution and Metronidazole HCL (concentration of 7.5mg/mL) + 5% Dextrose in water are stable up to 24 hrs at room temperature.

To read the full article Peer-reviewed Article PDF image

Author(s): Durga Mallikarjuna Rao Tippa and Dr N Singh

Keywords

Ceftriaxone Sodium, Reconstitution study, Intramuscular and Intravenous

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords