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A series of 1,4-disubstituted 1,2,3-bistriazoles was synthesized via click reacion by cycloaddition of bisalkynes with various organic azides. Synthesized triazoles were characterized by H1NMR and mass spectral techniques. All the compounds were evaluated for antioxidant and antifungal activities and found to possess moderate to good activities. The antioxidant activity of 1,4-disubstituted 1,2,3-bistriazole derivatives was determined by DPPH(1,1-diphenyl-2-picryl hydrazyl) assay. The antifungal activity was detected by agar well diffusion method against Aspergillus fumigatus.
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Author(s): Anthony P Bashir N Parveen R
Click chemistry, 1,4-disubstituted 1,2,3- bistriazoles, Antioxidant activity, Antifungal activity