alexa Abstract | Relationship between antifungal activity against <i>Candida albicans</i> and electron parameters of selected N-Heterocyclic thioamides

Indian Journal of Pharmaceutical Sciences
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Research Paper Open Access

Abstract

Due to the increasing demand for new pharmaceuticals showing biological activity against pathogenic microorganisms, there is increasing search for new compounds with predicted biological activity. Variously substituted thioamide derivatives with 1.3 and 1.2 ring of thiazole and 1,3,4-thiadiazole, as well as pyrazole were assessed for their activity against Candida albicans. Activity of majority of tested thioamides was larger as compared with that of the reference drugs. The electron parameters of obtained N-heterocyclic thioamides were determined and dependencies on their biological activity against Candida albicans were studied. The best electron compliance of produced bindings with the activity against Candida albicans was observed for the derivatives containing 1,3,4-thiadiazole ring.

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Author(s): Jadwiga Stachowicz Elzbieta KrajewskaKulak Cecylia Lukaszuk A Niewiadomy

Keywords

Thioamides, antifungal activity, Candida albicans, electron parameters

 
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