alexa Abstract | Relationship of Blood C - reactive protein (CRP) Level and Cognitive Deficit in Patients with Schizophrenia

International Journal of Collaborative Research on Internal Medicine & Public Health
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)


Introduction/Background: Increasing blood serum CRP level (C - reactive protein) in schizophrenic patients has been shown in recent studies and there have more emphasis on inflammatory aspects of schizophrenic disease. Aim & Objective: In current study, the purpose is to find and show the relationship between cognitive deficits in schizophrenic patients with blood serum CRP level.

Methods/Study: The statistical community, including patients with schizophrenia in the age range 18 to 65 years admitted to the Razi hospital in their diagnosis by an expert-based psychiatric diagnostic criterion (DSM-IV-TR) is definitive. Exclusion criteria for patients from the study is: 1) primary diagnosis of drug dependence, or sign of taking them, 2) a history of mental retardation, 3) having any history of clinical disorders that effect on cognitive vision, such as epilepsy and seizures, history of encephalitis or trauma (physical damage) to the skull or any central nervous system disorder. Using MMSE (Mini-Mental State Examination Questionnaire), 75 severely impaired cognitive patients were randomly selected. Also, in order to determine CRP serum, sample blood for fasting through immunoassay was measured, then through descriptive and inferential statistics, also showed and analyzed. In order to analyze the data in the description of frequency, percentage, mean and standard deviation, and in statistical inference of correlation, regression, ANOVA and t-test was used. Results/Finding: The results show that there is a positive significant correlation between cognitive deficit and serum CRP(r= 0.18, p<0.05). Also there is a significant correlation between cognitive deficit and age of schizophrenia onset(r=0.22 and p<0.01). Regression analysis was used to assess the role of serum CRP concentration to forecast cognitive deficit of the patients with schizophrenia (t= -2.2 & f=5 and p<0.05). Comparison of cognitive deficit between two high and low groups of CRP, Based on cut-off point of CRP test, subjects were divided into two groups and t-test was used to compare their cognitive deficit(t=2 & f=2.36 and p<0.05).

Discussion/Conclusion: Generally, such findings show the necessity to assess CRP in the patients with schizophrenia. Increased CRP is due to inflammation in patient's body, thereby using antiinflammatory drugs may establish a path towards decreased effects of schizophrenia or even improvement of the disease.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Nazila Diyanoosh Omid Rezaei Saeede Masafi Ali Nazeri Hadis Hoseynzade


Blood, high CRP serum, low CRP serum, cognitive deficit, schizophrenia

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version