alexa Abstract | Resealed erythrocytes: An engineering approach for drug delivery and drug targeting

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

The main objective of this review is to explore the various features, drug loading technology and biomedical application of resealed erythrocytes. Resealed erythrocyte becomes more popular because it has ability to circulate throughout the body, biocompatibility, zero order release kinetics of drugs, reproducibility and ease of preparation. Erythrocytes are biocompatible, biodegradable, possess long circulation half-lives and can be loaded with a variety of biologically active compounds using various chemical and physical methods (hypotonic dilution, hypotonic hemolysis, electro-insertion, entrapment by endocytosis, hypoosmotic lysis). These drug carriers are rapidly taken up from blood by macrophages of reticuloendothelial system (RES) present in liver, lung and spleen of the body. Wide varieties of drugs like Anti-inflammatory, steroidal and chemotherapeutic agents are seen to have reduced side effects upon incorporation into these carriers. Carrier erythrocytes are prepared by collecting blood sample from the organism & separating erythrocytes from plasma. By using various methods the cells are broken & the drug is entrapped into the erythrocytes, finally they are resealed and the ultimate carrier is referred to as “Resealed Erythrocytes”. The morphology, isolation techniques, properties and methods of drug loading are highlighted in this paper along with the characterization and applications of resealed erythrocytes, which hopefully put some light for researchers working in this area

To read the full article Peer-reviewed Article PDF image

Author(s): Ashutosh Mishra Roohi Kesharwani Arun K Tiwari Surendra Tripathy and Dilip K Patel

Keywords

Resealed Erythrocytes, Carriers, Encapsulation, RES, Phagocytosis, drug delivery and drug targeting

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords