alexa Abstract | Revealing hallmark histology of hippocampus neurons in beta-amyloid induced alzheimer’s mice and investigation of neuroprotective effect of Ipomoea aquatic forsk, an Indian medicinal herb

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access


Alzheimer’s disease (AD) is a potential neurodegenerative disorder of nervous system which affects the primary areas of the brain dealing with learning and memory. Deposition of the insolublebeta-amyloid protein on neurons activates the microglial cells which stimulates the process of neuroinflammation by releasing mediators. Release of cytokines and apoptotic promoters in turn shrink the neurons of the hippocampus leads to cognitive impairment. In the present study change in histology of hippocampi neurons in mice brain during AD will be evaluated by intra cerebro ventricular (ICV) injection of beta-amyloid 25-35.Toluidine blue, haematoxylin and eosin (H&E) staining methodswereutilized for analyzing the neuronal morphology of Cornuammonis (CA) and dentate gyrus (DG) zones of hippocampus. Results obtained from the histopathological study reveals that decrease in the number of hippocampi neurons may be due to degeneration. Presence of darken condensed nucleus, shrinkage of pyramidal cells in CA zones and decrease in granular cells of DG zone is a strong indication of apoptosis and stress cause by amyloid injection. Hence it was concluded that cognitive impairment caused by beta-amyloid in mice is mainly due to degeneration of neurons in functional zones of hippocampus that controls the memory and learning behavior.

To read the full article Peer-reviewed Article PDF image

Author(s): D Sivaraman P Panneerselvam and P Muralidharan


Alzheimer’s disease, beta-amyloid, hippocampus, intra cerebro ventricular, toluidine blue, haematoxylin and eosin, neuroinflammation., histology

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version