alexa Abstract | RNA Polymerase II: Reading in Loops to get Different Tails

Biochemistry & Molecular Biology Journal
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Abstract

The DNA-loops are necessary to recycle the RNA polymerase for the multiple transcription rounds of a gene. The nascent transcript needs to be 3’-end processed: cleaved in a specific position and added a 3´-end poly-(A)-tail to become an mRNA. Under regulated conditions, genes undergo 3´-end RNA processing at different positions. This is called alternative polyadenylation (APA) and, as a consequence, mRNA molecules could have different stabilities and regulated fates. The formation of alternative DNA loops is a key factor in order to get the APA.

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Author(s): MA FreirePicos

Keywords

RNA Polymerase, Transcription, Alternative polyadenylation, DNA loops, Molecular Immunology, Molecular Virology, Proteins and Nucleic Acids, Proteomics, Structural and Functional Genomics, Theoretical Bases of Biotechnology

 
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