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Mini Review Open Access
The DNA-loops are necessary to recycle the RNA polymerase for the multiple transcription rounds of a gene. The nascent transcript needs to be 3’-end processed: cleaved in a specific position and added a 3´-end poly-(A)-tail to become an mRNA. Under regulated conditions, genes undergo 3´-end RNA processing at different positions. This is called alternative polyadenylation (APA) and, as a consequence, mRNA molecules could have different stabilities and regulated fates. The formation of alternative DNA loops is a key factor in order to get the APA.
RNA Polymerase, Transcription, Alternative polyadenylation, DNA loops, Molecular Immunology, Molecular Virology, Proteins and Nucleic Acids, Proteomics, Structural and Functional Genomics, Theoretical Bases of Biotechnology