alexa Abstract | Role of antioxidant vitamin supplementation as a palliative treatment of bone disorders

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Abstract

A total of 198 patients of various bone disorders like osteoporosis, chronic renal failure, fractures and bone malignancy attending the OPD between October 2002 to May 2005 at Dr. D.Y. Patil Medical College, Hospital and Research Centre and Command Hospital, Pune were selected for the study. Assessment of the basal serum levels of biochemical markers like Tartarate resistant acid phosphatase (TrACP), Malondialdehyde (MDA), Alkaline phosphatase, free calcium (Ca++), Inorganic phosphorus (Pi), Superoxide dismutase (SOD) and erythrocyte reduced glu-tathione (GSH) was done. Then, the patients were divided into groups A (Vitamin E- Evinal 400 mg), B (Vitamin C- Celin 500 mg) and C (E+C) for administering antioxidants over a period of 90 days. Biochemical markers were reassessed in all the groups after 45 and 90 days of supplementa-tion. The results revealed that after 90 days supplementation there was significant reduction in serum MDA and serum ALP as compared to basal levels (p<0.001) in all three groups. Serum SOD and erythrocyte GSH showed significant increases compared to basal level (p<0.001 ) in all three groups . Serum TrACP was significantly reduced in group A and B (p<0.001) as compared to basal levels. Serum free calcium and phosphorus were unaltered. To conclude antioxidant vitamins E and C individually or conjointly improve bone meta-bolic status in skeletal disorders.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Alka N Sontakke Sarita A Shinde Umesh K More Vaishali V Dhat

Keywords

Oxidative stress, Osteoblastic and Osteoclastic markers, Bone disorders, vitamin E and C

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords