alexa Abstract | RP-HPLC method for the determination of cabazitaxel in bulk and injection dosage form

Journal of Chemical and Pharmaceutical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Original Articles Open Access

Abstract

An RP-HPLC method has been developed and validated for the quantification of cabazitaxel in injection dosage form. The desired chromatographic separation was achieved on the Inertsil ODS 3V (150 mm × 4.6 mm, 5 μm) HPLC column using isocratic elution at 254 nm detection wavelength. The optimized mobile phase consists of mixture of 0.1M NaH2PO4 and methanol in the ratio of 60:40 (v/v). The method showed linearity over the range of 24-72 μg/ml with regression coefficient value of 0.9999. The limits of detection and quantitation were found to be 0.052 μg/ml and 0.175 μg/ml, respectively. The recovery for all of the components was in the range of 100.394- 100.693% with percent relative standard deviation of less than 1%. The proposed method was successfully applied for the quantitative determination of cabazitaxel in injection dosage form.

To read the full article Peer-reviewed Article PDF image

Author(s): Suresh Kumar Raju Vidyadharani and Ravoori Sreenivasulu

Keywords

Cabazitaxel, Jevtana, Chromatography, Validation, Analysis, RP-HPLC

 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords