alexa Abstract | Screening and analysis of anti-A431 cell proliferative fraction of Euphorbia fischeriana Steud. extract

Biomedical Research
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article Open Access


To investigate the anti-human epidermal squamous-cell carcinoma A431 cell proliferative fraction of Euphorbia fischeriana Steud. and to determine chamaejasmine B content in the fraction. Anti-A431 cell proliferative activity of various Euphorbia fischeriana Steud. fractions, which were extracted using ethanol extraction and with different solvents, were screened by MTT assay to identify the active fraction. Chamaejasmine B content in the active fraction was determined by HPLC. Ethyl ether fraction showed more pronounced anti-proliferation activity on A431 cells. Ethyl ether fraction was the active fraction, in which chamaejasmine b content was 30.6%. IC50 of ethyl ether fraction of Euphorbia fischeriana Steud. for A43l cells at 48 h was 40 μmol/L. At this dose, A431 cell growth inhibition rate was (53.2 ± 0.31%). Ethyl ether extract is the anti-A431 cell proliferative fraction of Euphorbia fischeriana Steud. HPLC determination of chamaejasmine B content in active fraction is an accurate, reproducible and convenient method. We preliminarily conclude that the higher the chamaejasmine B content in the active fraction, the stronger its anti-proliferative effect on A431 cells.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Jiawen Wu Hong Sun Jia Huo Yuan Wang Jing Li


Euphorbia fischeriana Steud, Activity screening, A431 cell, HPLC, #

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version